Itruvone: A New Vomeropherine Approach to Major Depressive Disorder
The landscape of mental health treatment is constantly evolving as researchers seek more efficient ways to deliver therapeutic agents to the brain. One such innovation is Itruvone (developmental code PH10), a compound currently being developed by VistaGen Therapeutics. Designed as an intranasal spray, Itruvone represents a novel pharmacological approach to managing major depressive disorder.
Itruvone belongs to a chemical class known as vomeropherines. Unlike traditional oral antidepressants, which must pass through the digestive system and the blood-brain barrier, the intranasal route of administration allows for a more direct pathway toward the central nervous system, potentially improving the speed and efficacy of the treatment.
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Key Facts
- Generic Name: Itruvone (INN)
- Developmental Code: PH10
- Chemical Class: Vomeropherine
- Primary Indication: Major depressive disorder
- Administration Route: Intranasal spray
- Developer: VistaGen Therapeutics
Chemical and Technical Profile
Scientifically known as pregn-4-en-20-yn-3-one, Itruvone is a complex organic molecule with a specific stereochemical configuration. Its structure is defined by a steroid-like backbone, which is characteristic of the vomeropherine class.
Molecular Specifications
The compound has a molecular formula of C21H28O and a molar mass of 296.454 g·mol. Its precise IUPAC designation is (8S,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one.
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Identification Data
To ensure accuracy in clinical and laboratory settings, Itruvone is tracked via several global identifiers, including the CAS Number 21321-89-1 and PubChem CID 15633961. These identifiers allow researchers to verify the chemical purity and structure of the compound during the development process.
Summary of Itruvone Properties
| Property | Detail |
|---|---|
| Other Names | PH10, PH10A, PH10 NS, Pregn-4-en-20-yn-3-one |
| Drug Class | Vomeropherine |
| Molar Mass | 296.454 g·mol |
| CAS Number | 21321-89-1 |
| UNII | 72HML2UK6J |
| KEGG ID | D12542 |
Frequently Asked Questions
What is Itruvone?
Itruvone (PH10) is a vomeropherine compound currently under development by VistaGen Therapeutics for the treatment of major depressive disorder.
How is Itruvone administered?
It is formulated as an intranasal spray, allowing the medication to be delivered through the nasal passages.
What is the chemical name of Itruvone?
Its chemical name is pregn-4-en-20-yn-3-one.
Who is developing this medication?
The drug is being developed by VistaGen Therapeutics.
What is the molecular formula of Itruvone?
The molecular formula for Itruvone is C21H28O.