Filociclovir: A Promising Antiviral for Cytomegalovirus Treatment
In the ongoing effort to combat viral infections, Filociclovir (also known as cyclopropavir or MBX-400) has emerged as a significant investigational agent. Developed specifically to target complex viral structures, this drug represents a targeted approach to managing infections caused by double-stranded DNA viruses.
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What is Filociclovir?
Filociclovir is an antiviral medication designed primarily for the treatment of cytomegalovirus (CMV) infection. CMV is a common virus belonging to the herpesvirus family that can cause serious health complications, particularly in immunocompromised individuals.
Beyond its primary target, Filociclovir has demonstrated activity against other double-stranded DNA viruses, expanding its potential utility in clinical settings. In the United States, it is currently classified as an Investigational New Drug, meaning it is undergoing rigorous testing to determine its safety and efficacy for public use.
Clinical Progress and Development
The development of Filociclovir has progressed through the critical stages of medical research. It has successfully reached Phase II human clinical trials. This stage is vital as it evaluates the drug's effectiveness in a larger group of patients and further assesses its safety profile before moving toward final regulatory approval.
Key Facts
- Primary Use: Treatment of cytomegalovirus (CMV) infection.
- Spectrum: Active against various double-stranded DNA viruses.
- Clinical Status: Currently in Phase II human clinical trials.
- US Legal Status: Classified as an Investigational New Drug.
- Alternative Names: Cyclopropavir, MBX-400.
Chemical and Technical Specifications
From a chemical perspective, Filociclovir is identified by the IUPAC name 2-amino-9-[(Z)-[2,2-bis(hydroxymethyl)cyclopropylidene]methyl]-1H-purin-6-one. Its molecular structure is optimized to interfere with viral replication.
| Property | Value |
|---|---|
| Molecular Formula | C11H13N5O3 |
| Molar Mass | 263.257 g·mol |
| CAS Number | 632325-71-4 |
| PubChem CID | 135409256 |
| ChemSpider ID | 2276035 |
| UNII | EAO0TD9B13 |
Frequently Asked Questions
What is the primary purpose of Filociclovir?
Filociclovir was developed as an antiviral drug specifically for the treatment of cytomegalovirus (CMV) infections.
Does Filociclovir work against other viruses?
Yes, in addition to CMV, it has shown activity against other types of double-stranded DNA viruses.
What is the current clinical trial status of Filociclovir?
The drug has reached Phase II human clinical trials to evaluate its efficacy and safety.
Is Filociclovir approved for general use in the US?
No, it is currently listed as an Investigational New Drug in the United States.
What are the other names for Filociclovir?
It is also referred to as cyclopropavir and MBX-400.